The Tellier lab is interested in understanding how RNA polymerase II transcription and co-transcriptional processes, including pre-mRNA splicing and mRNA cleavage and polyadenylation, are regulated in mammalian cells. 

To achieve this we are using a combination of genomics, transcriptomics, bioinformatics, and microscopy techniques in human cell lines and mouse embryonic stem cells. 

Ultimately, our motivation is to understand how trasncription and RNA processing are regulated in normal cell biology to develop therapeutic approaches to counteract their dysregulations in cancer and other human diseases.